Superantigen immune stimulation evokes epithelial monocyte chemoattractant protein 1 and RANTES production.
نویسندگان
چکیده
Bacterial superantigens (SAgs) have been implicated in inflammatory disease, and SAg-treated mice have increased jejunal T cells. Here we show that T84 cells (a human epithelial cell line) display increased MCP-1 and RANTES mRNA expression and protein production in response to conditioned medium from Staphylococcus aureus enterotoxin B (SEB; a model SAg)-activated immune cells. Also, MCP-1 and RANTES mRNAs were increased in jejunal enterocytes isolated from SEB-treated mice. We suggest that T-cell recruitment to the gut following SAg immune activation could be partially due to epithelium-derived chemokines.
منابع مشابه
Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression.
To delineate the mechanisms that facilitate leukocyte migration into the cystic fibrosis (CF) lung, expression of chemokines, including interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and RANTES, was compared between CF and non-CF airway epithelia. The findings presented herein demonstrate that, under either basal conditions or tumor necrosis factor-α (TNF-α)- and/or interfero...
متن کاملMonocyte chemoattractant protein 1 (MCP-1) released from Helicobacter pylori stimulated gastric epithelial cells induces cyclooxygenase 2 expression and activation in T cells.
BACKGROUND and aims: To clarify the interaction between gastric epithelial and mucosal T cells, we examined the role of cytokines released from epithelial cells in response to Helicobacter pylori water extract protein (HPWEP) in regulating T cell cyclooxygenase 2 (COX-2) expression and activation. METHODS Media from MKN-28 cells incubated with HPWEP for 48 hours were added to Jurkat T cells a...
متن کاملComparative Potency of Green Tea and Red Wine Polyphenols in Attenuating Staphylococcal Superantigen-Induced Immune Responses
Proinflammatory cytokines mediate the toxic effects of staphylococcal exotoxins (SE). This study compared the potency of two polyphenols, green tea epigallocatechin gallate (EGCG) and red wine resveratrol (RES), in blocking the pro-inflammatory effects of staphylococcal enterotoxin B (SEB) and toxic shock syndrome 1 (TSST-1). Both EGCG and RES dose-dependently inhibited superantigen-stimulated ...
متن کاملCell-specific expression of RANTES, MCP-1, and MIP-1alpha by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus.
Respiratory syncytial virus (RSV) is the major cause of acute bronchiolitis in infancy, a syndrome characterized by wheezing, respiratory distress, and the pathologic findings of peribronchial mononuclear cell infiltration and release of inflammatory mediators by basophil and eosinophil leukocytes. Composition and activation of this cellular response are thought to rely on the discrete target c...
متن کاملInterferon ã induces diVerential upregulation of á and â chemokine secretion in colonic epithelial cell lines
Background—Production of chemoattractant factors by the intestinal epithelium may contribute to mucosal infiltration by inflammatory cells in inflammatory bowel disease. Secretion of the á chemokine interleukin 8 (IL-8), a neutrophil chemoattractant, has been widely studied, but little is known about epithelial secretion of â chemokines, which are preferentially involved in recruiting monocytes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Infection and immunity
دوره 67 11 شماره
صفحات -
تاریخ انتشار 1999